Let’s Talk About…Methylation, Glutathione, and Vitamin B12

May 25

by Dr. Jerry Kartzinel on 25 May 2011 in , , , with 9 Comments

The Methylation Pathway seems to be linked to many chronic diseases, including the autism that many children are diagnosed with. A “pathway” merely describes a factory that produces a product.  The Methylation factory produces glutathione similar to the way a Ford Factory produces pick up trucks.  Just like a truck factory requiring numerous steps to produce a finished product, the Methylation factory has lots of steps required before producing the finished product: glutathione.   

Glutathione is very important in maintaining and restoring physical health, and even mental health.   We know that children with autism tend to have lower levels of glutathione when compared to neurotypical children.  We also know that families that genetically tend to have lower amounts of glutathione, that is, their factories just produce lower amounts of glutathione,  also tend to have problems with schizophrenia, alcoholism, bi-polar disease, depression, attention deficit disorder, constipation, and autism.  Glutathione is essential for protecting cells from toxins - it is our master anti-oxidant, and seems to play in FOCUS, CONCENTRATION, AND LANGUAGE.

We can actually increase our body’s ability to produce glutathione….even if we are genetically challenged!  Dr. Jill James proved that we can increase the production of glutathione by supplying our Methylation factories with necessary key ingredients.

Methyl B12: this is vitamin B12 in its “methyl” form.  It can be given with a nose spray, subcutaneous injection, or orally.  It seems to work best for some in a nose spray (if the child tolerates it) or subcutaneous injection.  Dosing is variable based on age and weight, and how you are going to administer it (intranasal or subcutaneous).

Vitamin B6: aides in the production of glutathione.

Folic acid: this is a B vitamin that works as a cofactor in the Methylation factory.  This can be combined in the B12 injection or in the nasal spray.  For some children this can be rather activating and can cause hyperactivity, and thus will have to be removed.

Dimethylglycine: also known as DMG.  DMG also supports the Methylation pathway as a “methyl donor”.  

Trimethylglycine: also known as TMG.  TMG is DMG plus another methyl group.  Again, we are trying to provide the assembly line of the factory an “incentive” to make more glutathione.

Methionine: an amino acid that can be considered the “chassis” or the starting molecule that can eventually be transformed to glutathione

N-acetyl cysteine: also known as NAC.  This is precursor for cysteine and glutathione

In addition to providing supplements to aid in the production of glutathione, you can also supplement glutathione directly.  It can be given as an IV infusion, inhaled with a nebulizer, rubbed in as a cream, and orally (which I usually do not recommend since it seems to enhance the growth of yeast).

Improving the function of the Methylation pathway impacts many functions of the cell, right down to how DNA is read.  What the parents report, and what we are commonly after, is the improvement of language!  It appears that when we improve glutathione production, many children can make significant improvements with focus, concentration, and language.

And that’s my approach to Methylation.

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  • Hi Zsuzsanna Hay, we can help guide you in the right direction. Please send us an email at [email protected]

    Posted by GR GR, 11/05/2012 7:06pm (5 years ago)

  • I am interested in the biomedical support for my little man. We live in Australia and I can't seem to find any DAN practitioners at all. Can you please help.

    Posted by zsuzsanna Hay, 11/05/2012 5:14pm (5 years ago)

  • How soon can you start this with your child? My son is 18 months weighs 26 pounds.

    Posted by Stephanie Franklin, 06/04/2012 6:14pm (5 years ago)

  • According to the Vitamin D Council, Vitamin D deficiency results in glutathione deficiency. This makes sense, as bipolar disorder, MS, depression, and many others INCLUDING AUTISM are linked with vitamin D deficiency. Why is there no mention of Vitamin D in your approach to methylation?

    Posted by Alison Fujito, 12/12/2011 2:19pm (5 years ago)

  • Hi Dr. Jerry, my son has attention deficit and I tried to give DMG before. But, it caused hyperactivity to him and I stopped. What else I can do?

    Posted by Bee Ng, 20/10/2011 6:55am (5 years ago)

  • Would this product increase yeast overgrowth and did your child have yeast overgrowth when he took it?

    Posted by Marsha Kendall, 28/08/2011 3:05pm (6 years ago)

  • What are the dosages and combinations of these supplements?

    Posted by howard brass, 01/07/2011 2:33pm (6 years ago)

  • This is so true.My son has been taking Max GXL (a Glutathione Accelerator Supplement )for over a year now and has had a dramatic response to this. He is no longer exhausted, he can focus and concentrate at school, his eye contact is now better than most adults, his grades have improved significantly and he is now seizure free .

    Posted by Sue Barron, 18/06/2011 7:45pm (6 years ago)

  • My son had a dramatic response to taking a "Glutathione accelerator " product called Max GXL. Sam is 13 years attending a normal school and displaying virtually none of his Autism characteristics. He is now also seizure free. His grades as school have dramatically improved- he is no longer tired and has the ability to concentrate and focus. His eye contact would be better than most adults and he is calm and happy. Max GXL contains N-acetyl cysteine as well as 8 other ingredients that work synergistically to improve Glutathione levels by 276% as shown in the clinical study. It has certainly changed my sons life as well as my own and many other kids I know with Autism.

    Posted by Sue Barron, 18/06/2011 7:26pm (6 years ago)

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